|
KMID : 1161420170200100944
|
|
Journal of Medicinal Food
2017 Volume.20 No. 10 p.944 ~ p.950
|
|
|
Cardioprotective Effects of a Phlorotannin Extract Against Doxorubicin-Induced Cardiotoxicity in a Rat Model
|
|
Ahn Hyo-Suk
Lee Dong-Hyeon
Kim Tae-Jung
Shin Hyeon-Cheol
Jeon Hui-Kyung
|
|
|
Abstract
|
|
|
|
Long-term therapy with doxorubicin (DOX) is associated with high incidence of cumulative and irreversible dilated cardiomyopathy. The goal of this study was to evaluate the cardioprotective effects and safety of a phlorotannin extract from a brown algae Ecklonia cava (Seapolynol™, SPN) against DOX-induced cardiotoxicity in a rat model. A total of 42 rats were divided into six groups: control, low-dose SPN (LDS), high-dose SPN (HDS), DOX, DOX with low-dose SPN (DOX+LDS), and DOX with high-dose SPN (DOX+HDS). Echocardiography was performed at baseline and after 6 weeks. In left ventricular (LV) ejection fraction, DOX and DOX+LDS groups showed significant decreases (P?
|
|
|
KEYWORD
|
|
|
doxorubicin-induced cardiomyopathy, echocardiography, Ecklonia cava, electron microscopy, phlorotannin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|